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Two Endocannabinoids - Anandamide (AEA) And 2-AG

Two Endocannabinoids - Anandamide (AEA) And 2-AG

Endocannabinoids are substances produced from within the body and activate cannabinoid receptors (CB1 & CB2). CB1 receptors can be found in the central nervous system (CNS), particularly in the cortex, basal ganglia, hippocampus, and cerebellum. CB2 receptors are dominantly present in microglia and vascular elements. [1]

Anandamide was discovered first and can be found in almost all tissues in a wide range of animals. We can even find it in some of the plants like chocolate 🍫

2-AG [2] can mainly be found in the brain 🧠which might be the reason why CBD or other phytocannabinoids (CBG, THC etc.) can be a major help with long-term depression (LTD) or schizophrenia. CBD directs your body to make more use of its endocannabinoids. Therefore it is neuroprotective, anti-inflammatory, and analgesic. [3]

AEA & 2-AG are major members of the endocannabinoid family. They have been regarded almost like twin brothers. Both help with the regulation of synaptic functions and in behavioral aspects, such as learning and memory, reward and addiction, antinociception (reduced sensitivity to pain), and anxiety.

AEA & Anandamide are highly present in our nervous system. They serve as signaling molecules that are released from one cell and activating the cannabinoid receptors present on other nearby cells.

FUN FACT: The Endocannabinoid 2-AG has been found in human maternal milk

 

Sources:

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789136/

[2] https://en.wikipedia.org/wiki/2-Arachidonoylglycerol

[3] https://www.sciencedirect.com/science/article/pii/S1074552112001445

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