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Chronic Pain And CBD Oil

Chronic Pain And CBD Oil

Pain is the most common reason people report using cannabis products. The reason being is the number of side effects of very addictive drugs used for pain.  Over 120 people die every day from opioid overdoses in the US alone. Opioids were approved by the FDA based on the reassurance from pharmaceutical companies that they were not addicting. 

Cannabis Is A Great Alternative ( far less addictive)

Even combining cannabis with lower doses of opioids is a better option than just prescription drugs. 

The Endocannabinoid System plays a critical role in pain. Endogenous cannabinoids like Anandamide or 2-AG active CB receptors, eg. pain receptors. Furthermore, higher levels of the above-mentioned Endocannabinoids are associated with reduced acute and chronic pain in animals. Anandamide and 2-AG are susceptible to metabolism by inflammatory enzymes like cyclooxygenase (COX) and lipoxygenase (LOX) that produce molecules increasing pain perception. 

Imagine firefighters trying to quench a fire with clogged water hoses and simultaneously seeing gasoline being poured on the active fire. The same happens within our bodies when pro-inflammatory enzymes are elevated reducing endogenous cannabinoids to reduce pain and increase molecules that heighten pain. It is very simple for the situation to worsen and get out of control.

One of the keys to the ECS’s ability to regulate pain related to various conditions is the location of endocannabinoid receptors at neuronal synapses involved in pain processing (spinal, supraspinal, and peripheral levels). Moderate to high levels of CB1 receptors are found in structures that transmit and process pain signals like nociceptors (sensory receptors that detect painful stimuli), the dorsal horn of the spinal cord, thalamus and more. [1]

CB1 receptor act as a gate that opens and transmits pain signals detected by the peripheral nervous system (nociceptor sensory nerves) to the central nervous system.  In the central nervous system, CB1 receptors either enhance or reduce the transmission of pain signals to the brain. It is almost like a Wi-Fi router that is determining which signals can proceed to a peripheral device like a computer or phone and what speed the device receives these signals. 



Pain, whether from a broken finger or arthritis, is processed in the brain right alongside areas of the brain focused on emotional regulation. 

CB2 receptors play an important role in pain signaling, particularly chronic pain. Its primary role Is in blocking the release of pro-inflammatory (increase inflammation) and pronociceptive (trigger pain) mediators. By doing so, CB2 receptors reduce inflammation and excessive pain responses.   

Overall, The Endocannabinoid system Widely influences multiple mechanisms that cause pain. Clinical use shows that cannabinoids are more effective for chronic pain than acute pain. Chronic pain is a more complex process (psychophysiological) that involves changes in neurotransmission and sustained plasticity changes in both the peripheral and central nervous systems. 

Clinical Studies  

A clinical study observed a pain-relieving effect of CBD in people with chronic pain after a kidney transplant. Oral use of 100 mg per day of CBD completely resolved chronic pain in 28.6% Of participants, partially resolve pain in 57.2% of participants, and watch in effect and 14.2%. Common adverse effects include nausea, dry mouth, dizziness, drowsiness, and occasional hot flash feelings.  No serious adverse effects were observed. [1]

Activating The CB2 receptors might be very beneficial in managing chronic pain syndrome such as CRPS which stands for Chronic Regional Pain Syndrome. [2]

At least 10 randomized, controlled trials on over 1000 patients have demonstrated the efficacy of cannabinoids for neuropathic pain of various origins. [3]



It is recommended to start with the micro dose to test sensitivity and go up as needed within the dosing range by body weight until symptoms subside. [4] Begin with 10-40 mg of CBD per day. Oils that are high in CBD and low in THC can produce desired effects for some patients. When pain is localized, topical products can be applied.

It is suggested that patients work with a healthcare practitioner experienced in recommending CBD or medicinal Cannabis so that dosage and delivery methods can be developed and fine-tune on an individual basis.

As with most remedies, bodyweight significantly influences is the amount of CBD required to produce desirable results. Here’s a general guide for estimating the amount of CBD to take based on body weight per dose, as three divided doses

The book “ The Endocannabinoid System And Cannabis” suggested the following dosage:

Oral 2.5-20 mg CBD up to three times daily 

vaporized 900 mg cannabis providing 3.56% THC, three times daily 




[3] The Endocannabinoid System And Cannabis: The Perfect Partnership for Self-Regulation and Healing by Scott A. Johnson, Amp, Ceeos, Ccma, CPC

[4] CBD - A patient’s guide to medicinal cannabis by Leonard Leinow & Juliana Birnbaum


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